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Question Answer
What are the three acetylcholinesterase inhibitors (AChE inhibitors) that are used to treat Alzheimers?
Show Answer
Cognex/tacrine, donepezil/Aricept & rivastigmine/Exelon.
How often is tacrine/Cognex given daily?
Show Answer
4 times a day
What are the risks associated with tacrine/Cognex?
Show Answer
It is hepatotoxic and shouldn't be given to patients with existing renal or liver disease.
How does food consumption impact the availability of tacrine/Cognex, does it increase absorption, decrease absorption or prevent GI problems?
Show Answer
Decreases drug availability, it shouldn't be taken with food.
Which AChE isn't associated with hepatoxicity, but causes GL upset and weight loss?
Show Answer
Exelon/rivastigmine
What are common side effects of AChE inhibitors?
Show Answer
Bradycardia and hypotension


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